Department of Genome Engineering

dr hab. Marta Olejniczak

Dr. habil. Marta Olejniczak

Head of Department

marta.olejniczak@ibch.poznan.pl
ext. 1136

Researchers:

Dr. Paweł Śledziński
adiunkt

Magdalena Dąbrowska MSc
asystent

Research Projects

Research area

Research in the Department of Genome Engineering is currently focused on three major areas:

  • Development of genome editing technologies and methods for assessing its effectiveness and specificity
  • The use of genome editing technology to establish disease models and in cell and pre-clinical therapy of genetic diseases
  • The use of genetic tools in experimental therapy for polyglutamine diseases
Keywords
  • genome editing,
  • CRISPR/Cas9,
  • Cpf1,
  • genetic therapy,
  • RNA interference,
  • miRNA,
  • Huntington’s disease

Research activity

  • Generation of a new cellular model based on the CRISPR-Cas technology (enChIP) to study mechanisms of DNA repair in microsatellite regions - MINIATURA 5
  • NCN, SONATA BIS - The use of genetic tools in the experimental therapy of polyglutamine diseases
  • NCN, OPUS - Investigation of DNA double-strand break repair mechanisms in microsatellite regions using the CRISPR-Cas9 system
  • NCN, PRELUDIUM BIS - Allele-selective therapy for polyglutamine diseases with the use of RNA interference technology
  • NCN, ETIUDA – The use of genome editing systems in experimental therapy for polyglutamine disorders
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