Department of Medical Biotechnology

dr hab. Agnieszka Fiszer

Dr. habil. Agnieszka Fiszer

Head of Department:

agnieszka.fiszer@ibch.poznan.pl
ext. 1450

Researchers:

Dr. Magdalena Jazurek-Ciesiołka
adiunkt

Dr. Emilia Kozłowska
adiunkt

Dr. Adam Ciesiołka
adiunkt

Dr. Magdalena Woźna -Wysocka
adiunkt

Dr. Paweł Świtoński
adiunkt

Research Projects

Research area

Research performed in our Department has been focusing on trinucleotide repeats sequences and their expansion related to human neurological diseases. This group of diseases includes polyglutamine (polyQ) diseases: Huntington’s disease (HD) and several spinocerebellar ataxias (SCA).   

Main research topics carried out in our Department are:

  • screening for RNA and protein toxicity markers in polyglutamine diseases,
  • establishment and characteristics of new cellular and mouse models,
  • investigation of proteins interaction with trinucleotide repeats tracts in RNA,
  • design and testing of oligonucleotide-based therapeutic strategies,
  • mechanisms responsible for gene expression silencing by siRNA and miRNA,
  • evaluation of non-coding RNAs role in pathogenesis of polyglutamine diseases.
Keywords
  • triplet repeat expansion diseases,
  • Huntington’s disease, 
  • pathogenesis, 
  • RNA toxicity, therapeutic startegies, 
  • RNA interference technology, 
  • microRNAs, 
  • non-coding RNAs, 
  • iPSC technology, cellular models, 
  • mouse models

Research activity

Ongoing research projects:

  • Identification of CAG repeat-binding proteins and imaging RNA-protein interactions in cells (NCN OPUS, PI: A. Ciesiolka)
  • RAN translation at CAG repeats in spinocerebellar ataxia type 3 (NCN SONATA, PI: M. Jazurek-Ciesiołka).
  • Investigation of initial pathways of DRPLA pathogenesis in human neural precursors (MNiSW Diamentowy Grant, PI: B. Nowak) 
  • Experimental validation of spinocerebellar ataxia type 3 pathogenesis markers that were identified by high throughput methods (NCN MINIATURA, PI: G. Figura)
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