Department of Molecular Neurooncology

dr hab. Katarzyna Rolle

Dr. habil. Katarzyna Rolle

Head of Department

kbug@ibch.poznan.pl
Phone: 618291860 office, 618291866 lab

Researchers:

Dr. Julia Misiorek
adiunkt

Dr. Dariusz Wawrzyniak
adiunkt

Julia Latowska-Łysiak MSc
adiunkt

Research Projects

Research area

The main goal of the Department of Molecular Neurooncology is the complex research of the basics of development and progression of brain tumors, especially glioblastoma multiforme (GBM). Our interests include mainly:

  • the identification and characteristics of the regulatory RNAs crucial for the cancer development, such as miRNA, lncRNA and circRNA, especially their importance for cancer stem cells and processes like: unlimited cell divisions, ability to form secondary tumors, or eventually resistance to chemotherapy,
  • the establishing the role of extracellular matrix (ECM) components in metastases, resistance to treatment and processes associated with epithelial-mesenchymal transition,
  • the identification of RNA molecules with potential diagnostic, prognostic and therapeutic significance.

In our experimental approach we use a combination of molecular biology tools, in vivo imaging techniques with functional studies using clinical tissue samples, human cell lines (including primary tumor cells isolated from patients) and syngeneic mouse tumor models.

Keywords
  • brain tumors,
  • glioblastoma multiforme,
  • cancer development and progression,
  • cancer stem cells,
  • regulatory RNAs,
  • circular RNAs, miRNAs,
  • extracellular matrix,
  • epithelial-mesenchymal transition

Research activity

  • Functional crosstalk between circRNAs and extracellular matrix (ECM) - the importance for glioblastoma stem cells (GSC) and epithelial-mesenchymal transition (EMT) in brain tumors. NSC – OPUS 13
  • The characteristics of the regulatory RNAs landscape in glioblastoma multiforme (GBM). Circular RNAs and micro RNA-like molecules as a new players in gilomagenesis and GBM progression and their importance for glioblastoma stem cells (2018-2022). NSC – SONATA BIS 7
  • Catalytic RNAs as a tool for human mitochondrial biotechnology. NCN – PRELUDIUM 11
  • New, multifunctional nanoparticles for combined photothermal and gene silencing cancer therapy. NCN – OPUS 11
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