Department of Non-coding RNAs

dr hab. Marta Olejniczak

Dr. Monika Piwecka

Head of Department

monika.piwecka@ibch.poznan.pl
Phone:​​ 61 8291855

Researchers:

Dr. Marcin Koliński
Postdoc

Dr. Ewelina Kałużna Postdoc

Research Projects

Research area

We are a group of researchers interested in uncovering functions of non-coding RNAs in mammalian neurons, glial cells and neuroendocrine system. 
Our studies concern:

  • expression patterns of ncRNAs in single cells of the central nervous system, among its cell types, and subtypes,
  • subcellular localization of regulatory RNAs in neurons and neuroglia,
  • ncRNA: protein interactions,
  • regulatory ncRNA networks,
  • functional aspects of ncRNA,
  • deregulation of non-coding transcriptome in CNS/neuroendocrine system pathologies.
Keywords
  • regulation of gene expression,
  • RNA biology,
  • non-coding RNAs,
  • circular RNAs (circRNAs), miRNAs, lncRNAs,
  • RNA:protein interactions,
  • transcriptomics,
  • scRNA-seq,
  • neuroscience,
  • systems biology

Research activity

We are currently specifically focusing on circular RNAs (circRNAs), miRNAs, and some lncRNAs. In our projects, we apply cutting-edge new technologies, such as single-cell RNA sequencing (scRNA-seq) and RNA imaging at a single-molecule resolution, knockdown studies of selected ncRNAs with CRISPR-Cas13 technology along with developing new methods for studying RNA: protein interactions. We take advantage of interdisciplinary efforts of molecular, cellular, and systems biology as well as neuroscience to address the question of how ncRNAs shape the regulatory networks in neurons and other neural cell types.

Funding

  • NCN, Opus (2021-2024) – project „Non-coding RNAs at single-cell resolution in the pituitary gland and their role in the regulation of gene expression”
  • NCN, Sonata Bis 8 (2019-2023) – project „Functional implications of brain-enriched circular RNAs”
  • NAWA, Polish Returns 2019 (2019-2023) – project „Deciphering networks of regulatory RNAs in the central nervous system”
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