Prof. Jerzy Ciesiołka
Head of Department:
Dr. habil. Jan Wrzesiński associate professor
Dr. habil. Mariola Dutkiewicz adiunkt
Dr. habil. Agata Świątkowska
Joanna Szpotkowska MSc
Martyna Kabacińska MSc specjalista biolog
Marek Kazimierczyk MSc PhD student
Structural and functional analysis of sequence variants of the 5' non-coding region of p53 mRNA: characterization of the structure of this region and its role in the translation process; elucidating the role of different p53 protein isoforms synthesized in the cell; identification and characterization of proteins interacting with the 5' non-coding region of p53 mRNA.
Coxsackie B3 virus research: searching for highly conserved RNA structural elements in the CVB3 virus genome and their structural and functional analysis; development of a rational strategy for attacking viral RNA using oligonucleotide tools; virus-cell interactions.
Application of embryonic and mature kidney cells as a model of cultured human stem cells to understand the different stages of development of this organ: analysis of the expression of non-coding RNAs using new sequencing methods; characterization of the interaction of various molecules with long non-coding RNAs in human cells.
Schematic representation of secondary structures for variants of p53 mRNA 5'-terminal region. Colors denote parts of the 5'-terminal region of p53 mRNA: black – 5' untranslated region downstream P1 promoter; orange – p53 open reading frame (ORF); blue – region between P0-P1 transcription promoters; green – intron 2.
The 5'-terminal region of p53 mRNA and complementary antisense oligonucleotides. Modulation of the p53 and Δ40p53 translation initiation process by antisense oligomers in HepG2 cells upon stress conditions.
Secondary structure model of the 5' UTR of coxackievirus B3 with color lines indicating the target sites of helper 2’-O-methyl-16-mers (ome No) and siRNAs (si No). siRNA-induced silencing of the reporter construct hrGFP-5’UTRcvb3 in the absence and presence of helper oligomers.
Interaction of long noncoding RNA with cellular partners.
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