Department of RNA Structural Genomics

dr hab. Marcin K. Chmielewski

Prof. Elżbieta Kierzek

Head of Department

elzbieta.kierzek@ibch.poznan.pl
ext.​ ​​1113, 1112

Researchers:

Dr. Marta Soszyńska-Jóźwiak
adiunkt

Dr. Marta Szabat
adiunkt

Research Projects

Research area
  • RNA structural genomics of viruses
  • Secondary and tertiary structure of RNA and its complexes with functional proteins, other RNA and small molecules
  • Modulation RNA functional activities, including pathogenic RNAs involved with human diseases
  • RNA structural genomics of influenza virus, influence of RNA structure on virus replication
  • Study of structure and interactions of selected segments of influenza virus vRNA(-) and RNA(+) and important for function structural motifs of virus RNA in vitro and in vivo.
  • Determination in the RNA of influenza virus the regions of modified oligonucleotides and ligands strong binding
  • Improving microarrays mapping method with isoenergetic microarrays
  • Projecting and optimization of modified oligonucleotides, siRNA, ribozymes and ligands as potential inhibitors of influenza virus life cycle.
  • Study of structures and interactions of complexes of influenza virus vRNA(-) and virus nucleoprotein (NP).
  • Inhibition and regulation of influenza virus proliferation – cells studies.
  • Modified oligonucleotides – antisense and microarrays strategies.
  • Oligonucleotide carriers and bioconjugates.
  • CRISPR/Cas systems as strategies for replication inhibitors of RNA viruses.
  • Thermodynamic and comparison analysis of studied RNA, prediction of RNA secondary structure.
  • Studies of functional RNA structural motifs of SARS-CoV-2 virus
  • Modified oligonucleotides with inhibitory activities against SARS-CoV-2 virus proliferation
  • Searching for small molecules that inhibit SARS-CoV-2 virus proliferation
  • Cells tests of potential inhibitors of SARS-CoV-2 virus replication
  • Binding site and structural foundations for disruption of SARS-CoV-2 virus replication by inhibitors
Keywords
  • RNA structural genomics,
  • RNA viruses,
  • influenza virus,
  • SARS-CoV-2,
  • COVID-19,
  • isoenergetic microarrays,
  • modified microarray probes,
  • nucleic acids thermodynamics of nucleic acids,
  • modified oligonucleotides,
  • antisense oligonucleotides,
  • siRNA,
  • small molecules,
  • RNA structure,
  • RNA interactions, pathogenic RNA

Research Projects

  • SARS-CoV-2 RNA, target for inhibition of virus replication, (NSC, EXPRESS CALL TO FUND RESEARCH ON COVID-19)
  • Function of secondary structure of influenza A virus vRNA in ribonucleoprotein complex during viral life cycle, (NSC, Sonatina)
  • Modified siRNAs, ribozymes and CRISPR/Cas system as strategies for influenza A virus inhibition. Application and comparison of RNA-targeting methods, (NSC, Preludium)
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