Department of Structural Biology of Prokaryotic Organisms

kbrzezinski@ibch.poznan.pl

Dr. habil. Krzysztof Brzeziński

Head of Department

kbrzezinski@ibch.poznan.pl
ext. 1125

Researchers:

Dr. Paweł Drożdżal
adiunkt

Dr. Piotr H. Małecki 
asystent

Research Projects

Research area

To develop novel inhibition strategies against enzymes of pathogenic origin, a broad range of methods from the intersection of microbiology, biochemistry, biophysics including macromolecular crystallography  and NMR spectroscopy, must be applied. Our studies concern:

  • Structural enzymology of S-adenosyl-L-homocysteine hydrolases of various origin.
  • Development of species-specific inhibitors targeting the enzyme dynamics.
  • High-throughput macromolecular crystallography.
  • Crystallographic studies of biologically active small molecules.
  • X-ray diffraction studies of non-crystalline (bio)materials.
Keywords
  • Macromolecular crystallography
  • Small molecule crystallography
  • Structural enzymology
  • Protein-ligand interactions
  • Antibiotic resistance
  • Cellular methylation
  • S-adenosyl-L-homocysteine hydrolase

Research activity

Inhibition of S-adenosyl-L-homocysteine hydrolase from Pseudomonas aeruginosa by targeting the enzyme dynamics
NCN SONATA BIS 8

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